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Should be avoided in individuals with active or historical malignancy

Unlike injectables, Takedas Takhzyro (lanadelumab) or Ionis/Otsukas Dawnzera (donidalorsen) which require parenteral administration and target kallikrein deucrictibant offers more direct, receptor-level blockade of bradykinin signaling

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It lays early groundwork for larger trials that could tease apart whether the reduced alcohol use people report on GLP-1s is mostly neurological or more pharmacokinetic in nature