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In addition to appetite suppression, semaglutide GLP-1 slows gastric emptying, meaning that food remains in the stomach longer, enhancing the feeling of satiety after meals

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Pyruvate oxidation flux was determined by calculating the rate of 14 CO2release from [2- 14 C]-pyruvate (Sigma Aldrich) as previously described [126]

In this context, DHODH, a mitochondrial inner-membrane enzyme traditionally known for its role in de novo pyrimidine biosynthesis, was proposed to also function as a CoQ 10 oxidoreductase and ferroptosis suppressor