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Identification of type 2 diabetes loci in 433,540 East Asian individuals

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--- 7 Contraindications / Cautions Sick sinus syndrome Bradycardia Peptic ulcer disease Asthma/COPD Concomitant anticholinergic drugs (reduce effect) --- 8 Drug Interactions Anticholinergics Oppose action CYP3A4 inhibitors (e.g., ketoconazole) levels CYP inducers (e.g., rifampicin) levels Beta-blockers risk of bradycardia --- 9 Comparison With Other Drugs Drug Selectivity Half-life Notes Donepezil CNS selective Long Once daily Rivastigmine Less selective Shorter Patch available Galantamine Moderate Moderate Also enhances nicotinic receptors --- Clinical Pearls Best tolerated among cholinesterase inhibitors No titration beyond recommended schedule Improvement seen in 46 weeks Stop if no clinical benefit To view or add a comment, sign in Overview of the common classes of antihypertensive drugs, their mechanisms, examples 1