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Cagrilintide combined with semaglutide (CagriSema) for treatment of type 2 diabetes In a recent small phase 2 trial (n=92), 3 groups of patients with type 2 diabetes were randomized to receive cagrilintide co-administered with semaglutide (the authors called this combination CagriSema), cagrilintide or semaglutide, both in doses escalated to 2.4 mg once weekly (table 1) [10]

The Lancet 2023 trial in patients with type 2 diabetes reported approximately 16.9% mean weight loss in the highest dose group at 36 weeks alongside significant HbA1c reductions, demonstrating that the weight loss effect persists in the presence of diabetes and concurrent glucose-lowering effects

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