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P., & Londero, R

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18 investigated the foliar application of spermidine, spermine, and putrescine (at 0.5, 1, and 2.5 mM) on secondary metabolites and antioxidant activity of potted Calendula officinalis flowers, reporting significant increases in total phenolic content, flavonoids, and antioxidant capacity

The observation that higher plasma concentrations of 2 can be achieved after oral delivery than for PZQ, coupled with the greater ex vivo potency of compound 2 , strongly suggest that further optimization will yield an orally bioavailable schistosomicidal agent that will be transformative in the clinical setting