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Phase II clinical trials published in Circulation showed SS-31 improved left ventricular function and exercise capacity in heart failure patients, with 28% improvement in 6-minute walk distance compared to placebo (Daubert et al., 2017)

PMID:17322063

Key insights: Strong anti-hyperglycemic and antihyperlipidemic effects Hepatoprotective benefits observed Stable renal parameters (favorable safety profile) Combination with atorvastatin showed moderate benefit, but cinnamon alone demonstrated stronger metabolic improvement These findings highlight the potential of Cinnamomum zeylanicum as a complementary therapeutic strategy in diabetes management warranting further clinical investigation