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Another study using primary cortical neurons cultured from Pink1 -deficient mice revealed that FKBP5 can reduce Akt phosphorylation and promote MPP + -mediated neuronal death in the absence of Pink1 [91]

Moreover, preclinical RF models exhibit significant limitations: UUO and I/R models induce acute severe fibrosis that does not mimic the gradual progression of human CKD-related RF and lacks comorbidities (e.g., diabetes and hypertension) that are common in clinical settings

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