Like GLP-1, it affects hunger and food intake
En las recomendaciones de tratamiento farmacolgico de la DM2 hay consenso en que la terapia inicial es la MF a menos que est contraindicada y cuando con esta no se logra control, est indicada la terapia dual
This oxidative imbalance might stabilize and activate NRF2 by disrupting its KEAP1-mediated degradation ( de novo GSH synthesis ( The PARK7 gene, which encodes the DJ-1 protein, is a causative gene for autosomal recessive early-onset Parkinsons disease ( 2.3 CHAC1 and ferroptosis Programmed cell death is an actively regulated process, governed by a complex network of genes and proteins, that is critical for normal physiological functions across organisms ( In mammals, ferroptosis has been implicated in diverse pathologies, including neurodegenerative diseases, stroke, traumatic brain injury and kidney degeneration, as well as in carcinogenesis, where it may exert a tumor-suppressor function
Subsequently, M2 phenotype is polarized from macrophages and primarily responsible for tissue repair and anti-inflammatory pathways via producing mediators such as IL-10 and TGF- [29]
