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NNMT regulates methylation of nicotinamide, influencing intracellular pools of NAD+, a central cofactor in metabolic pathways

HF-TMS over the left DLPFC is shown to have a superior effectiveness compared to sham treatment in individuals with depression even when used without concomitant antidepressant (118, 119), and has the benefit of accelerating clinical response (120) and also effective as a monotherapy for both unipolar or bipolar depression (121)

Preclinical investigations have highlighted its ability to stimulate mucosal proliferation and improve gastrointestinal homeostasis