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3.2 Direct hepatocyte protection: membrane stabilization and antioxidant effects 3.2.1 Membrane stabilization The amphiphilic structure of glycyrrhizin enables it to intercalate into the phospholipid bilayer of hepatocyte membranes, primarily in the outer layer

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10.1016/J.NEURO.2012.01.015 196 WilsonD

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Finally, dosage is an issue

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The exact contribution of particular CYP isoforms to APAP bioactivation varies and depends on the concentration of the drug

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