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Sample sizes varied widely between studies, from 239 in ONeil to 4974 in SCALE Obesity and Prediabetes (Table 1)

Hausner, H., Derving Karsbl, J., Holst, A.G., Jacobsen, J.B., Wagner, F.D., Golor, G., Anderson, T.W

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However, the relevance of these findings to humans remains uncertain, as human thyroid C-cells have much lower expression of GLP-1 receptors compared to rodents