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118 Compared to the hypoinflammatory subphenotype, the hyperinflammatory subphenotype was characterized by higher plasma levels of inflammatory biomarkers, a greater incidence of vasopressor use, lower serum bicarbonate levels, and a greater incidence of sepsis, with higher mortality and fewer ventilator-free days (VFDs) and organ failure-free days in both the ALVEOLI and ARMA cohorts

This was the upper limit of quantitation of assays performed in the early days of research regarding paracetamol poisoning and has empirically been maintained as the definition for liver injury since then *

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394,395 These markers are frequently overexpressed in CSC populations across multiple cancer types, making them attractive candidates for CAR-T-cell therapy (NCT02541370, NCT02915445, and NCT03013712)