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Switching from Injectable to Oral# Recommendation : Orforglipron Reason : ATTAIN-MAINTAIN showed that patients switching from injectable semaglutide or tirzepatide to oral orforglipron maintained their previously achieved weight loss, validating oral step-down therapy

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Unlike previous reports, which have largely been based on post-marketing reports and FDA safety monitoring, the researchers used active comparator groups and multiple sensitivity analyses to minimise bias, providing more robust real-world evidence

This is characterized by increased expression of pro-inflammatory genes (IL-1, IL-6 and TNF-) and decreased expression of anti-viral and antibody genes (e.g., IFNs) [71]