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In phase 1 studies, brensocatib reduced NE levels in blood with acceptable safety and pharmacokinetics (194, 201), prompting a 24-week phase 2 WILLOW trial conducted in 256 patients with bronchiectasis, in which treatment with 10 mg or 25 mg of brensocatib daily for 24 weeks significantly prolonged time to exacerbations compared with placebo (115, 202)

Intralingual succinylcholine administration in children: An alternative to intravenous and intramuscular routes

Acute gallbladder disease events, such as cholecystitis or cholelithiasis, have been reported in clinical studies with semaglutide

Some benefits may be subtle, and formal cognitive assessments can be helpful in tracking progress