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Preclinical studies suggest GLP-1 agonists may reduce synovial macrophage infiltration and decrease production of matrix metalloproteinasesenzymes responsible for cartilage degradation in RA

Notably, current pharmacological strategies for metabolic disorders have identified the normalization of MERCS connectivity as a pivotal therapeutic target (Magalhaes Rebelo et al., 2020

The participants also saw 1.6 percent average drop in A1C levels, a measurement that estimates average blood sugar levels over the previous two to three months

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