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These limitations matter, and they are why the formal recommendation remains cautious

Different from the function of most tight junctions (such as occludin, claudin-1, ZO-1), the expression of claudin-2 protein increases the cell bypass permeability, leading to the destruction of the intestinal epithelial barrier and the increase in bacterial translocation and transmission, and then resulting intestinal dysbiosis [90, 91]

General Section, 98 (1), 1-13

There are recommended maintenance doses for both drugs: Zepbound maintenance doses: 5 mg, 10 mg, or 15 mg Wegovy maintenance doses: 1.7 mg or 2.4 mg (injection), 25 mg (pill) However, your maintenance dose may differ, depending on your response to the medication and your healthcare providers discretion