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In clinical trials: Semaglutide: Approximately 7% discontinued due to adverse events Tirzepatide: Approximately 4-7% discontinued due to adverse events (dose dependent) Retatrutide: Approximately 6-10% discontinued due to adverse events (dose dependent) These rates are relatively close, suggesting that despite the differences in mechanism and side effect profiles, all three medications are tolerable for the vast majority of people who start them

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Also, the Singapore Chinese Health Study with a follow-up cohort of 9.9 years revealed that the consumption of lutein and zeaxanthin was negatively correlated with the risk of hip fractures in men with a lower body mass index [38]

Once you know your BMR (either from a formula or using Edens calculator), you choose the multiplier that best matches your routine