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Berberine, sometimes marketed as "Nature's Ozempic," has emerged as a potential alternative

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Mice with homozygous null mutation for the most abundant glutathione peroxidase, GPx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide

However, this limitation does not fully prevent its clinical utility as a glutathione precursor: once deacetylated cysteine reaches target cells, intracellular synthesis proceeds effectively