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Intensive performance protocols are reserved for short-term studies focused on acute performance markers like substrate oxidation or mitochondrial respiration, where higher frequency justifies the added complexity

We specifically used common clinical factors that are available within current clinical practice to build our model, making it more feasible for use in real-world settings

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However, their opposing pharmacodynamic effects create a clinical conflict: prednisone increases appetite hormones (ghrelin, neuropeptide Y) while GLP-1 agonists suppress these same pathways