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doi: 10.3389/fphar.2025.1654372 Received 26 June 2025 Accepted 05 August 2025 Published 18 August 2025 Volume 16 - 2025 Edited by Abbas Choudhury, VIT University, India Reviewed by Evelyn Weaver, The Pennsylvania State University (PSU), United States Marcelo Adrian Estrin, Interamerican Open University, Argentina Updates Copyright 2025 Zeng, Luo, Ou, Gan, Huang, Tomlinson and Jiang

However, the "safety" of any supplement often comes down to the quality of the ingredients and the lack of synthetic fillers

Intracerebroventricular administration study The intracerebroventricular study was performed in HFHS-fed C57BL/6J mice that were single-housed in open cages

It is best taken with a full glass of room-temperature water at least 30 to 60 minutes before meals, or a minimum of 2 hours after eating