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The concordance with molecular assays is around 95% and is higher for genotype 1 than for the others.57,60 In cases of discrepancy, the sequencing of reference genomic regions, such as NS5B and E1, generally confirms the result of the molecular assay.61 Mixed serologic reactivity is sometimes observed

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Commercially available NGS panels must contain genes known at the time of their marketing to be effective and must be updated as frequently as possible to include more recently identified genes

While those numbers are worth noting, theyre comparable to or lower than what is observed with Semaglutide (which saw 7-11% discontinuation across trial arms) and suggest manageable tolerability for most participants