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In 2025, Novo Nordisk submitted Orforglipron for regulatory review by the FDA, but it is not yet approved

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In summary, in this 26-week dose-finding study, oral semaglutide demonstrated robust efficacy for A1C reduction and weight loss, with the 20 mg and 40 mg once-daily doses of oral semaglutide producing similar glycemic and weight benefits when compared with injectable semaglutide

In 2025, Novo Nordisks semaglutide awaits several first-time FDA decisions: Injectable GLP-1s 2025 Ozempic for T2DM and peripheral artery disease (PAD) 2H 2025 Wegovy for heart failure with preserved ejection fraction (HFpEF) and obesity Oral GLP-1s October 2025 new indication for oral Rybelsus for secondary CV risk reduction 4Q 2025 the first oral GLP-1 ( oral formulation of Wegovy 25 mg ) for weight loss and weight loss plus secondary CV risk reduction Given the considerable continued growth expected in the GLP-1 pipeline, Prime Therapeutics (Prime) talented team of clinical experts actively monitors this emerging landscape