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For example, the proposed rule addendum shows 3.71 RVUs (or $124.61) per square centimeter for QPs and $123.99 for non-QPs, both below the proposed $125.38 as described in the rule

A major obstacle to acquisition of metal cofactors by apoenzymes is that the binding sites for these cofactors frequently lack the capacity to discriminate between different divalent metal cations and cofactors (Waldron et al., 2009)

However, some may experience side effects

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