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Snacks: A handful of nuts, a hard-boiled egg, or a piece of cheese

While melasma induced by pregnancy or photosensitizing drugs has a better outcome after the causative factor ceases, most patients experience a chronic disorder, with seasonal variation and relapses after successful treatment, requiring post-treatment maintenance

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Cell culture Swiss 3T3 fibroblasts, obtained from American Type Culture Collection (ATCC CCL 92), were maintained at 37 in Dulbecco's modified Eagle's medium supplemented with 25 mM HEPES (pH 7.4), 10% (v/v) fetal bovine serum, 100 units/mL penicillin, and 100 mg/mL streptomycin