Histone modification, a posttranslational alteration occurring at specific sites on chromatin histones, encompasses various modifications, such as acetylation, methylation, phosphorylation, ubiquitination, and minor ubiquitination, with acetylation being the most prevalent
Inclusion criteria required patients aged 1875 years with UC diagnosis at least 3 months prior, moderate to severe disease defined as mMS 4 with MES 2, and prior treatment with at least one conventional therapy or first biological agent use, while excluding patients with CD, rectal-limited disease or colon involvement under 15cm and toxic megacolon
mass-spec identity confirmation
Common Side Effects Gastrointestinal Issues: Bloating or diarrhea may occur, particularly at higher doses