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combined bleeding risk is theoretical but not well-quantified in RCTs Monitoring required / fasting lipid panel at baseline, 4 weeks, then every 8 weeks on isotretinoin Typical omega-3 doses studied / 1 to 4 g EPA+DHA daily Vitamin A warning / high-dose fish liver oils (e.g., cod liver oil) add retinol

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Intermediate effect sizes are considered biologically meaningful because average proportions of variance explained in physiological, ecological and evolutionary studies are usually below 7% 32

Colton (who hasnt even worked on this case) stopped me to ask how my mares wound was healing