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Source: Employer Benefit Research Institute April 16, 2026 GLP-1 medications for obesity carry a well-documented discontinuation problem, and stopping them typically means regaining weight and the return of cardiometabolic risk factors

When you see the "L" prefix, it refers to the specific chemical orientation of the molecule

Chem Biol Interact 368:110170

"It shows this drug develops some sort of therapeutic resistance that makes it not as effective anymore." RELATED | How GLP1 drugs work on body and brain against obesity Doctors say weight loss from GLP-1 medications typically includes a mix of 40 percent muscle and 60 percent fat