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Journal of Clinical Investigation, 124(10), 44734488

However, the coexistence of persistent exertional dyspnea, unrefreshing sleep, postexertional malaise, and reduced stamina, combined with major limitations of the daily activities, likely indicates pathologic fatigue

Although certain side effects have been reported more commonly with semaglutide than with tirzepatide, trial data suggest that such differences may be a reflection of variation in background (i.e., placebo group) rates in the enrolled trial populations, with the proportional increase in many side effects when compared to placebo being similar for the 2 agents (Table 2)