A standard research dose (e.g., 100mcg) might produce a mild, barely noticeable flush
Targeted release in localized areas MNs systems could be used to achieve localized therapeutic effects by targeting molecular modifications, modulating the local physiological environment and employing specific delivery strategies
Patience through the first week is normal
Summary Keywords acute lymphoblastic leukemia, methotrexate, glutathione, metabolomics, drug resistance, arsenic trioxide, thioredoxin reductase Citation Canevarolo RR, Melo CPS, Cury NM, Artico LL, Corra JR, Lau YT, Mariano SS, Sudalagunta PR, Brandalise SR, Zeri ACM and Yunes JA (2022) Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines