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Cardiovascular Outcomes Liraglutide (LEADER trial): 13% reduction in major adverse cardiovascular events (MACE) in patients with Type 2 diabetes and high cardiovascular risk Statistically significant cardiovascular protection Semaglutide (SELECT trial): 20% reduction in MACE in patients with obesity and established cardiovascular disease Studied specifically for cardiovascular outcomes in obesity (not just diabetes) Both medications provide cardiovascular protection, but semaglutides evidence is more recent, more robust, and specifically applicable to patients with obesity regardless of diabetes status
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
Vitamin C ensures the collagen is built correctly and the glutathione stays active and effective throughout the day
Understanding this distinction matters because more potent does not automatically mean more effective for a given patient
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