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Study Selection Two reviewers (R.K

Additionally, among SASP factors, there are growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and insulin-like growth factor 1 (IGF-1), which, when secreted into the environment by senescence cells, stimulate the repair and regeneration of surrounding tissues [13]

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This gap in understanding accentuates the need for additional research into how mitochondrial dysfunction affects the development and progression of DE