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However, its not yet understood whether synephrine alone or combined with other stimulants causes these symptoms ( Summary Bitter orange contains a compound called synephrine that may boost metabolism and encourage weight loss

Melatonin and inflammationStory of a double-edged blade

Research in humans is a bit less impressive Clinical trials in humans A 1981 double-blind study found that chronic insomniac patients found that subjects slept 59% more, shorter sleep latency, and higher sleep efficiency (Schneider 1981) A 1987 double-blind study did not find any statistically significant changes in sleep structure as measured by REM sleep, NREM sleep, or total sleep time (Debellis 1987) A 1992 double-blind study in 14 chronic insomnia patients found higher sleep efficiency and subjectively estimated tiredness decreased to similar levels of healthy subjects in 7 nights of injections (Schneider 1992) There are some limitations to these studies however

Cycles 2 and 3 typically show the most meaningful changes in body composition, sleep quality, and recovery