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Pathological staging also significantly impacts the selection of protective strategiesmelatonin levels are significantly reduced in tumor patients, with advanced cervical cancer patients showing notably lower melatonin levels than early-stage patients, which suppresses melatonins protective effects in vivo (194)

As of 2026, Eli Lilly has progressed retatrutide into Phase 3 clinical trials, with data expected to inform regulatory submissions in the coming years [10]