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Benham JL, Booth JE, Sigal RJ et al (2021) Systematic review and meta-analysis: SGLT2 inhibitors, blood pressure and cardiovascular outcomes

Its anti-inflammatory mechanism centers on actin sequestration TB-500 binds to G-actin monomers, regulating cytoskeletal dynamics that are critical for inflammatory cell migration and wound healing

So the deeper diaphragmatic nasal breathing can control a little bit of that cortisol release as well