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There are three primary mechanisms by which CLAs are thought to reduce inflammation and oxidative stress: (1) CLA competes with linoleic acid in production of arachidonic acid, which itself is a precursor to prostaglandin E2, and thus CLA reduces the production of prostaglandins, by affecting the expression of cyclooxygenase 2 enzyme [62]

But changing this axis can also create side effects, including fluid retention, changes in glucose regulation, carpal tunnel-like symptoms, headaches and theoretical concerns in people with cancer risk or proliferative disease

Furthermore, our review introduces potential novel metformin-based interventions that may merit consideration in future research

Extremely well known