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115 Cerebral insulin resistance may arise from the downregulation of insulin transport across the blood-brain barrier secondary to chronic peripheral hyperinsulinemia and systemic insulin resistance 116 as well as from the loss of neuronal membrane insulin receptors induced by soluble amyloid-beta (A) oligomers

a , F o F c composite omit maps of glutathione (green) and (-)-catechin ( 12 ) (orange) in the ternary complex rendered at 3

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