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Researchers eventually determined that its primary biological function involves transporting long-chain fatty acids across the mitochondrial membrane for energy production

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Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17

A final round of alignment-free 3D Classification to remove structural heterogeneity revealed the IFnarrow and IFwide states, as well as a third state (IFtransition) in which NBD2 was poorly resolved