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In the Phase 2 OASIS trial, participants on the 12mg dose lost an average of 24.2% of their starting body weight over 48 weeks

Clinical experience suggests that fatigue is often most pronounced during the initial dose escalation phase, when the body is adapting to the medication's effects on appetite, gastric emptying, and glucose metabolism

Bypassing gastric channels and hepatic intervention activity by intravenous loading protocol presents a model for resolving these deficits

Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders