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Dehydration or a low-fiber diet are common causes of constipation that can be addressed with lifestyle changes

Tesamorelin is a stabilized peptide analogue of growth hormone-releasing hormone (GHRH) while ipamorelin is a growth hormone-releasing secretagogue

The TRIUMPH programme is evaluating retatrutide across multiple indications including chronic weight management, type 2 diabetes, knee osteoarthritis, moderate-to-severe obstructive sleep apnoea, chronic low back pain, cardiovascular and renal outcomes, and MASLD

At this point, medical oncology was consulted and believed the best course of action would be to discontinue the upadacitinib and monitor the KS for progression while switching him to vedolizumab for management of his UC