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GLP-2 has also been described inside the pancreatic islets, and a glucagonotropic effect occurs after intravenous administration of GLP-2 to patients ( 3.5 Oxyntomodulin Another interesting peptide is oxyntomodulin (OXM), a peptide related to GLP-1 and GLP-2 obtained from proglucagon processing by PC1/3 in L cells along the intestine but also at the caudal part of the nucleus of the solitary tract in the Central Nervous System (CNS) ( in vitro and in animal models ( 3.6 PYY PYY is a molecule co-secreted with GLP-1 by intestinal L cells

The lysosomal protein and sfGFP delivered to the lysosome are degraded and inactivated

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