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In SAMP mice, which naturally exhibit accelerated aging and genome instability, Epitalon treatment stabilized chromatin structure, supporting a preventative mechanism rooted in epigenetic control and DNA repair [61] One of the most compelling cancer prevention models is the HER-2/neu transgenic mouse, engineered to spontaneously develop mammary tumors

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Decrease dose if: Experiencing consistent side effects (headaches, fatigue, GI disturbance), achieving satisfactory results at current dose with no need for escalation, or cost considerations favor using minimum effective dose