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Whilst this exploratory analysis was underpowered, there was a significant reduction in response to twice-daily exenatide in carriers of p.S539W compared with non-carriers (-0.84%, 95%CI [-1.56, -0.12], p = 0.023), whilst directionally consistent there was no significant difference between carriers of p.D563G (-0.19%, 95% CI [-0.66, 0.27], p = 0.41)
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