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Upper/Lower Gastrointestinal Symptoms Adverse event reporting databases, RCTs, and real-world data consistently show that GLP-1 RAs are commonly associated with GI symptoms such as nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspeptic complaints

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Berenbaum F, et al

But because people on semaglutide or tirzepatide lose more weight in the first place, they all end up returning to baseline at approximately the same time, said senior researcher Dimitrios Koutoukidis of Oxford University