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Rhein inhibited ferroptosis and EMT to attenuate diabetic nephropathy by regulating the rac1/NOX1/-catenin Axis

Specifically, rats that were given 200 mg of NPs per kg of body weight daily showed a significant increase of approximately 2.7 times, 1.9 times, and 2.3 times in the generation of ROS, MDA, and NO, respectively, compared to rats given a daily dose of 25 mg per kg of body weight (Hozayen et al

In addition, they found that Ex-4 influenced astrocytes subjected to OGD/R by down-regulating the protein of phosphor- Janus Kinase 2 (pJAK2)/signal transducer and activator of transcription 3 (STAT3), which is a novel and previously undiscovered GLP-1 signaling pathway (101)

Wegovy has shown promise in improving MASH. If confirmed in larger trials, GLP1 drugs could become a cornerstone of liver disease management