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Glutathione peroxidases modulate NF-B activation, which has been confirmed by the following considerations: inhibitors of cyclo-oxygenases and lipooxygenases inhibited activation of NF-B, the activity of cyclo-oxygenases depends on the hydroperoxide tone which is regulated by glutathione peroxidases, NF-B activation was inhibited in selenium-supplemented cells and facilitated in selenium deficiency

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