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IGF-1 serum levels are markedly higher in patients with advanced gastric cancer than in those with early-stage disease and are associated with a Helicobacter pylori positive status (15)

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Description of drug classesMetformin Metformin is an effective drug, affording an expected mean HbA1c reduction of 1.3% to 2.0%, particularly when routinely used as the first option at the diagnosis of DM2 with elevated HbA1c levels.21 Despite extensive experience in the use of the drug, we have only recently advanced in our knowledge of its mechanism of action

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