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DOX has been found to induce the production of reactive oxygen species, thereby synergistically upregulating the expression of MDR1 and BRCP in conjunction with the high activity of HIF-1 under hypoxia

In the efficacy study with obese monkeys, the dosing regimen that produced the 11% body weight loss and 39% fat deposit reduction over 28 days was not precisely detailed in all publications, but researchers described managing doses to balance efficacy against renal function

Nobody disputes the biochemistry