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Incorporation of this highly acidic polar group, may well assist in the solubility of these new squarate sweeteners, in carbonated food preparations [140 ]

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Abbreviations GAC: Green analytical chemistry GSH: Glutathione NAC: N-acetyl l-cysteine Vit-C: Vitamin C HPLC: High-performance liquid chromatography UV: Ultraviolet HPTLC: High-performance thin-layer chromatography KOH: Potassium hydroxide LOD: Limit of detection LOQ: Limit of quantification SD: Standard deviation RSD: Relative standard deviation FTIR: Fourier transmission infrared spectroscopy IR: Infrared ICH: International conference on harmonization HCl: Hydrochloric acid NaOH: Sodium hydroxide H 2 O 2 : Hydrogen peroxide References Duperray J, Sergheraert R, Chalothorn K, Tachalerdmanee P, Perin F (2022) The effects of the oral supplementation of l-cystine associated with reduced l-glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark-and placebo-controlled clinical trial

No adverse clinical signs were observed in any NAC-treated animals during the study