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A 2024 preprint randomized placebo-controlled pilot study examined repeated NAD+ IV administration in healthy adults and reported preliminary findings on bioavailability and tolerability, while noting that the evidence base for this delivery route requires further controlled investigation

Ibuprofen causes stomach irritation and bleeding, while acetaminophen poses a higher risk of liver damage if taken in excess.

In Pevec et al.s rat model study, crushed gastrocnemius muscle complexes in untreated controls showed minimal spontaneous recovery