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The trial has two main arms: A structured lifestyle intervention program with intensive coaching and support A structured-lite version of the same core program with fewer touchpoints Both arms of the lifestyle trial will separately assess the impact of adding a metabolism-targeting drug such as a GLP-1 agonist to determine which combination offers the greatest cognitive protection

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Role of PPAR- in diabetes-induced testicular dysfunction, oxidative DNA damage and repair in leptin receptor-deficient obese type 2 diabetic mice